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Luis Ayala (1-2) was charged with the loss, after issuing a leadoff walk to pinch-hitter Scott Hairston to begin the deciding frame.
He slammed his bat in frustration before walking to first and was promptly removed in favor of Brian Bixler.
Glen Perkins got the final two outs of the contest to receive the first save of his career.
Mark Kotsay had a home run and triple while knocking in three runs, but also had a costly error in the Brewers' fifth loss in six games.
Houston, TX (Sportsbook Betting Lines) - Kevin Youkilis' bases-loaded walk in the top of the ninth forced in the deciding run as Boston clipped Houston, 2-1, in the finale of a three-game interleague set. Jacoby Ellsbury notched a pair of hits and Drew Sutton scored the deciding run for the Red Sox, who swept the series and have won four straight overall.
Mark Melancon (5-2) walked three in the ninth and took the loss.
After retiring Jason Varitek to start the ninth, Melancon walked pinch-hitter Sutton, then Ellsbury singled. Dustin Pedroia's fielder's choice left runners on the corners, and Adrian Gonzalez drew a free pass to load the bases. The move backfired as Youkilis followed by working a walk to force in Sutton and the Sox led, 2-1.
Houston struck in the fifth when Wallace hit a leadoff double and came around three batters later on a Sanchez pinch-hit RBI single.
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